Spatial compartmentalization of signal transduction in insulin a...

Spatial compartmentalization of signal transduction in insulin action Spatial compartmentalization of signal transduction in insulin action Christian A. Baumann and Alan R. Saltiel* Summary Insulin resistance is thought to be the primary defect in the pathophysiology of type 2 diabetes. Thus, under- standing the cellular mechanisms of insulin action may contribute significantly to developing new treatments for this disease. Although the effects of insulin on glucose and lipid metabolism are w