# Outlier-Immunized_Common_Harmonic_Waves_JBHI
https://pubmed.ncbi.nlm.nih.gov/37028067/
Hongmin Cai, Huan Liu, Defu Yang, Guorong Wu, Bin Hu, and Jiazhou Chen*. *“Estimating Outlier-Immunized Common Harmonic Waves for Brain Network Analyses on the Stiefel Manifold”*, IEEE Journal of Biomedical and Health Informatics, vol. 27, issue 5, pp. 2411-2422, May 2023.
*Abstract* — Since brain network organization is essentially governed by the harmonic waves derived from the Eigen-system of the underlying Laplacian matrix, discovering the harmonic-based alterations provides a new window to understand the pathogenic mechanism of Alzheimer’s disease (AD) in a unified reference space. However, current reference (common harmonic waves) estimation studies over the individual harmonic waves are often sensitive to outliers, which are obtained by averaging the heterogenous individual brain networks. To address this challenge, we propose a novel manifold learning approach to identify a set of outlier-immunized common harmonic waves. The backbone of our framework is calculating the geometric median of all individual harmonic waves on the Stiefel manifold, instead of Fréchet mean, thus improving the robustness of learned common harmonic waves to the outliers. A manifold optimization scheme with theoretically guaranteed convergence is tailored to solve our method. The experimental results on synthetic data and real data demonstrate that the common harmonic waves learned by our approach are not only more robust to the outliers than the state-of-the-art methods, but also provide a putative imaging biomarker to predict the early stage of AD.
*Index Terms* — Alzheimer’s disease, brain network, harmonic waves, manifold optimization
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估计Stiefel流形上用于脑网络分析的异常免疫共谐波matlab代码.zip
共200个文件
png:120个
m:34个
xlsx:21个
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估计Stiefel流形上用于脑网络分析的异常免疫共谐波matlab代码.zip (200个子文件)
bar_amy.eps 33KB
main.m 13KB
main.m 13KB
main_energy.m 8KB
permutationTest.m 7KB
permutationTest.m 7KB
permutationTest.m 7KB
permutationTest.m 7KB
barwitherr.m 6KB
calculate_individual.m 5KB
Outlier_Immunized_Harmonic_Wave_Estimated.m 4KB
Classification_Fourier_end.m 4KB
Classification_Fourier.m 4KB
Classification_original.m 3KB
Linear_SVM.m 3KB
Proprocess_original_Amyloid_data.m 2KB
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replicability_test_Pseudo.m 2KB
Proprocess_original_Tau_data.m 2KB
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Proprocess_original_FDG_data.m 2KB
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vis_simulated.m 2KB
replicability_test_Arithmetric.m 2KB
Energy_Cal.m 2KB
replicability_test_Frechet.m 1KB
replicability_test_Geometric.m 1KB
fisher_score_cL.m 1017B
Preprocess_data_np_noTransM_01.m 1008B
fisher_score_cal.m 789B
remove_outlier.m 499B
FDR_correct.m 424B
Calculate_rotation.m 280B
Energy_norm.m 166B
remove_node.m 145B
50_b_com_phi.mat 333KB
50_a_com_phi.mat 333KB
50_a_com_phi.mat 66KB
50_b_com_phi.mat 66KB
README.md 2KB
README.md 220B
mmse_amy_plot_1.pdf 31KB
circular_amy_new.png 126KB
outliers_new_35.png 30KB
outliers_new_20.png 30KB
outliers_new_15.png 29KB
outliers_new_5.png 28KB
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energy_bar_tau_cel_new.png 18KB
colormatrix15.png 14KB
energy_bar_fdg.png 12KB
energy_bar_amy.png 11KB
energy_bar_tau.png 11KB
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