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North America Equity Research
03 January 2019
Life Sciences Tools and Dx
Questions & Themes for J.P. Morgan Healthcare
Conference
Life Science Tools & Diagnostics
Tycho W. Peterson
AC
(1-212) 622-6568
tycho.peterson@jpmorgan.com
Bloomberg JPMA PETERSON <GO>
Tejas Savant
(1-212) 622-5650
tejas.savant@jpmorgan.com
Julia Qin
(1-212) 622-9253
julia.qin@jpmchase.com
Eleni Apostolatos
(1-212) 622-0136
eleni.apostolatos@jpmorgan.com
J.P. Morgan Securities LLC
See page 85 for analyst certification and important disclosures.
J.P. Morgan does and seeks to do business with companies covered in its research reports. As a result, investors should be aw
are that the
firm may have a conflict of interest
that could affect the objectivity of this report. Investors should consider this report as only a single factor in
making their investment decision.
www.jpmorganmarkets.com
Heading into our 2019 Healthcare Conference next week, we have aggregated key
themes and management questions for the 34 companies in our coverage universe
that will be attending (excluding PACB, given the planned ILMN merger). For
additional thoughts on the group, please see our recently-published 2019 Life
Science Tools Outlook and accompanying slides, while our updated thoughts on
med tech can also be found in the Med Tech Monitor. In addition, we will be
hosting four panels at the conference this year, with details below. Key themes:
2018 sector review: The life science tools space again outperformed broader
healthcare in 2018 (S5LSTS +13% YTD vs. XLV +0%), although premium
valuations, difficult comps and macro noise (rising interest rates, U.S.
midterms, drug pricing concerns, Brexit, FX headwinds and potential disruption
from tariffs and biopharma M&A), capped outperformance into year-end,
despite a solid fundamental backdrop across most end markets. Clearly,
investors have been willing to pay a premium for the stability offered by the life
sciences group, which remains an attractive (albeit expensive) relative safe
haven in the context of continued volatility in other healthcare sub-sectors,
including biotech, spec pharma, generics, distributors and PBMs. Within the
group, diagnostics had a particularly strong run in 2018, following several
acquisitions (e.g. Roche/FMI/Flatiron Health, MYGN/Counsyl), while more
recently benefitting from manageable/better understood PAMA headwinds (with
reimbursement for advanced LDTs shielded from deep cuts) and a rotation away
from tools in light of the aforementioned headwinds. In terms of end markets,
trends remain healthy across biopharma (biotech funding remains at near-record
levels), academic (improving funding environment globally, U.S. Government
shutdown aside) and industrial (U.S. PMI continues to hover near multi-year
highs, although OUS PMIs have moderated from peak levels), although we
continue to see signs of a rotation from growth-to-value with no follow-through
in the group following generally strong 3Q18 results.
2019 sector outlook: We expect organic growth to largely mirror 2018 for core
tools, against a fundamentally healthy backdrop across biopharma, industrial
and academic end markets, with China remaining a regional growth engine, with
the biggest obstacle being difficult comps. Importantly, we believe a case can be
made for growth to accelerate for some (A, DHR, PKI, TMO) as acquisitions are
added to the organic line for the year, while capital deployment remains an
important value creation lever for the fragmented industry. That said, despite
robust fundamentals, given a growth-to-value rotation in the broader market and
valuations that remain at/near highs (~15x forward EV/EBITDA), we believe
that companies with discounted valuations (HOLX, SYNH, XRAY) could do
better in a downturn, as long as they continue to execute on turnaround plans.
The biggest risks, in our view, are fund flows from growth to value (or from
equities to other asset classes) spurred by rising interest rates, an escalation in
trade war rhetoric (if it results in punishing tariffs on life science products) and
broader economic slowdown, while today’s biopharma M&A is likely to renew
fears of additional industry consolidation, which could pressure the CROs (and
to a lesser extent, core tools).
2
North America
Equity Research
03 January 2019
Tycho W. Peterson
(1-212) 622-6568
tycho.peterson@jpmorgan.com
Putting it together, our top picks for 2019 are Agilent (A) and Danaher (DHR),
which, in our view, have resilient business models (high recurring revenue mix and
much less cyclical industrial exposure) that remain attractive in a volatile
healthcare tape, clear paths toward continued organic acceleration and margin
expansion, with additional upside from M&A optionality (and in the case of DHR,
growth improving following the dental spin). Beyond that, we see upside potential
for turnaround stories with compelling valuations, including Dentsply Sirona
(XRAY), Hologic (HOLX) and Syneos Health (SYNH), and urge investors to take
advantage of any broader downturn to add exposure to long-term open-ended
growth stories, including Illumina (ILMN), Intuitive Surgical (ISRG) and Guardant
Health (GH), that trade at premium valuations, in light of the potential for upward
revisions to estimates throughout the course of the year.
3
North America
Equity Research
03 January 2019
Tycho W. Peterson
(1-212) 622-6568
tycho.peterson@jpmorgan.com
Panels at JPM Healthcare Conference
Reinventing the Disease Continuum Through Precision Health
Panel will explore the use of precision data and technologies across the full spectrum of disease, from population health and
prevention, to diagnosis and therapeutics, as well as shed light on the challenges and opportunities that accompany
precision health. CEOs of Illumina, Color, Exact Sciences and Adaptive Biotechnologies will share thoughts on the
applications of precision health beyond research settings across the disease continuum.
Monday @ 5:00 pm PST. Featuring:
Moderator:
Tycho Peterson, Managing Director, Equity Research Analyst, Life Science Tools & Diagnostics, J.P. Morgan
Panelists:
Francis DeSouza, President & CEO, Illumina
Othman Laraki, CEO, Color
Kevin Conroy, Chairman & CEO, Exact Sciences
Chad Robbins, Co-founder & CEO, Adaptive Biotechnologies
KOL Breakfast on Next Generation Sequencing
Dr. Chris Mason is an Associate Professor at Weill Cornell Medicine, with appointments at the Tri-Institutional Program in
Computational Biology and Medicine between Cornell, Memorial Sloan-Kettering Cancer Center and Rockefeller
University, the Sandra and Edward Meyer Cancer Center, and the Feil Family Brain and Mind Research Institute. He will
discuss key trends in next generation sequencing, including the sequencing instrument landscape, TAM expansion, liquid
biopsy, informatics hurdles, as well as regulatory and reimbursement dynamics that gate clinical adoption.
Tuesday @ 7:00 am PST. Featuring:
Dr. Chris Mason, Associate Professor at Weill Cornell Medicine
Liquid Biopsy Panel
Join us for a discussion on cancer molecular diagnostic testing, with an emphasis on liquid biopsy. We will learn about
entrenched and emerging technologies, and the evolving reimbursement and regulatory landscape. We will hear from CMS,
FDA, a prominent lab, as well as a current and former CEO for an interactive conversation regarding best practices, clinical
utility, intended use, next generation sequencing, payment trends, pricing, personalized medicine and the future.
Tuesday @ 5:00 pm PST. Featuring:
Moderators:
Tycho Peterson, Managing Director, Equity Research Analyst, Life Science Tools & Diagnostics, J.P. Morgan
Ipsita Smolinski, Managing Director, Capitol Street
Tejas Savant, Vice President, Equity Research Analyst, Life Science Tools & Diagnostics, J.P. Morgan
Panelists:
James Almas, MD, VP, National Medical Director for Clinical Effectiveness, LabCorp
Helmy Eltoukhy, PhD, Co-founder & CEO, Guardant Health
Paul Gerrard, MD, Medical Director, Palmetto GBA
Steve Kafka, PhD, Partner, Third Rock
Timothy Stenzel, MD, PhD, Director, Office of inVitro Diagnostics and Radiological Health, FDA
4
North America
Equity Research
03 January 2019
Tycho W. Peterson
(1-212) 622-6568
tycho.peterson@jpmorgan.com
Will 2019 Be The Year Precision Health Goes Mainstream?
The panel will discuss the emerging potential of precision health in the population health setting. Panelists will share
thoughts on current trends and the future potential of precision health for the broader population.
Wednesday @ 12:30 pm PST. Featuring:
Moderators:
Tycho Peterson, Managing Director, Equity Research Analyst, Life Science Tools & Diagnostics, J.P. Morgan
Christina Farr, Technology and Health Reporter, CNBC
Panelists:
Jill Hagenkord, MD, FCAP, Chief Medical Officer, Color
Stephanie Devaney, PhD, Deputy Director, All of Us Research Program, NIH
Kristen Murtos, MBA, Chief Administrative & Strategy Officer, Northshore University HealthSystem
Heidi L. Rehm, PhD, FACMG, Chief Genomics Officer, Center for Genomics Medicine, Massachusetts General
Hospital
David B. Nash, MD, MBA, Dean, Jefferson College of Population Health
Karen E. Knudsen, PhD, Enterprise Director, Sidney Kimmel Cancer Center at Jefferson
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