Roles of BRCA1 and its interacting proteins

Roles of BRCA1 and its interacting proteins Roles of BRCA1 and its interacting proteins Chu-Xia Deng� and Steven G. Brodie Summary Germline mutations of BRCA1 predispose women to breast and ovarian cancers. BRCA1 contains several functional domains that interact directly or indirectly with a variety of molecules, including tumor suppres- sors (p53, RB, BRCA2 and ATM), oncogenes (c-Myc, casein kinase II and E2F), DNA damage repair proteins (RAD50 and RAD51), cell-cycle regulators (cyclins and