Roles of BRCA1 and its interacting proteins
Roles of BRCA1 and
its interacting proteins
Chu-Xia Deng� and Steven G. Brodie
Summary
Germline mutations of BRCA1 predispose women to
breast and ovarian cancers. BRCA1 contains several
functional domains that interact directly or indirectly
with a variety of molecules, including tumor suppres-
sors (p53, RB, BRCA2 and ATM), oncogenes (c-Myc,
casein kinase II and E2F), DNA damage repair proteins
(RAD50 and RAD51), cell-cycle regulators (cyclins and
