Cortical spreading depression (CSD) is a pathophysiological phenomenon. There are sufficient evidences to prove that CSD plays an important role in some neurological disorders. However, exact mechanisms of its initiation and propagation are still unclear. Previous studies showed that glutamate receptors could be concerned with CSD, but those studies were mostly performed oriented to ionotropic glutamate receptors (iGluRs). There is relatively little report about effects of metabotropic glutamate
