Deceiving appearances: signaling by "dead" and "fractured" recep...

Deceiving appearances: signaling by "dead" and "fractured" receptor protein-tyrosine kinases Deceiving appearances: signaling by ``dead'' and ``fractured'' receptor protein-tyrosine kinases Michael Kroiher,1 Michael A. Miller,2 and Robert E. Steele3* Summary The mechanisms by which most receptor protein-tyro- sine kinases (RTKs) transmit signals are now well established. Binding of ligand results in the dimerization of receptor monomers followed by transphosphorylation of tyrosine residues wi