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Identification of a peptide
DNase II inhibitor enhancing
gene delivery
Nuclease activity is thought to be a
significant barrier to effective gene
delivery employing synthetic vectors.
In particular, the lysosomal DNase,
DNase II, has significant access to
plasmid DNA, when the protective
condensing agent has been shed.
Szoka et al. postulated that a DNase
II inhibitor would enhance transfection
by enabling a larger
