异丙酚对工作记忆任务大鼠前额叶皮层单神经元和神经元集合活动的抑制作用
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Behavioural
Brain
Research
270
(2014)
270–276
Contents
lists
available
at
ScienceDirect
Behavioural
Brain
Research
jou
rn
al
hom
epage:
www.elsevier.com/locate/bbr
Research
report
Inhibition
of
propofol
on
single
neuron
and
neuronal
ensemble
activity
in
prefrontal
cortex
of
rats
during
working
memory
task
Xinyu
Xu
a,1
,
Yu
Tian
a,b,1
,
Guolin
Wang
b
,
Xin
Tian
a,∗
a
Laboratory
of
Neurobiology
in
Medicine,
School
of
Biomedical
Engineering,
Tianjin
Medical
University,
Tianjin
300070,
China
b
Tianjin
Medical
University
General
Hospital,
Tianjin
300052,
China
h
i
g
h
l
i
g
h
t
s
•
Propofol
anesthesia
caused
short-time
working
memory
dysfunction.
•
Propofol
anesthesia
inhibits
single
neuron
activity
in
prefrontal
cortex.
•
Propofol
weakens
interactions
within
neuron
ensemble
in
the
prefrontal
cortex.
a
r
t
i
c
l
e
i
n
f
o
Article
history:
Received
12
March
2014
Received
in
revised
form
13
May
2014
Accepted
16
May
2014
Available
online
26
May
2014
Keywords:
Propofol
Working
memory
Prefrontal
cortex
Single
neuron
Neuron
ensemble
a
b
s
t
r
a
c
t
Working
memory
(WM)
refers
to
the
temporary
storage
and
manipulation
of
information
necessary
for
performance
of
complex
cognitive
tasks.
There
is
a
growing
interest
in
whether
and
how
propofol
anesthesia
inhibits
WM
function.
The
aim
of
this
study
is
to
investigate
the
possible
inhibition
mechanism
of
propofol
anesthesia
from
the
view
of
single
neuron
and
neuronal
ensemble
activities.
Adult
SD
rats
were
randomly
divided
into
two
groups:
propofol
group
(0.9
mg
kg
−1
min
−1
,
2
h
via
a
tail
vein
catheter)
and
control
group.
All
the
rats
were
tested
for
working
memory
performances
in
a
Y-maze-rewarded
alternation
task
(a
task
of
delayed
non-matched-to-sample)
at
24,
48,
72
h
after
propofol
anesthesia,
and
the
behavior
results
of
WM
tasks
were
recorded
at
the
same
time.
Spatio-temporal
trains
of
action
potentials
were
obtained
from
the
original
signals.
Single
neuron
activity
was
characterized
by
peri-
event
time
histograms
analysis
and
neuron
ensemble
activities
were
characterized
by
Granger
causality
to
describe
the
interactions
within
the
neuron
ensemble.
The
results
show
that:
comparing
with
the
control
group,
the
percentage
of
neurons
excited
and
related
to
WM
was
significantly
decreased
(p
<
0.01
in
24
h,
p
<
0.05
in
48
h);
the
interactions
within
neuron
ensemble
were
significantly
weakened
(p
<
0.01
in
24
h,
p
<
0.05
in
48
h),
whereas
no
significant
difference
in
72
h
(p
>
0.05),
which
were
consistent
with
the
behavior
results.
These
findings
could
lead
to
improved
understanding
of
the
mechanism
of
anesthesia
inhibition
on
WM
functions
from
the
view
of
single
neuron
activity
and
neuron
ensemble
interactions.
©
2014
Elsevier
B.V.
All
rights
reserved.
1.
Introduction
Propofol
(2,6-diisopropylphenol)
is
widely
used
for
surgical
anesthesia
and
sedation
in
postoperative
care.
In
recent
years
there
are
some
research
reports
about
human
memory
dysfunc-
tion
caused
by
propofol
anesthesia
[1–3].This
phenomenon
has
also
been
observed
in
animal
models.
Propofol
anesthesia
decreased
∗
Corresponding
author.
Tel.:
+86
02283336951;
fax:
+86
02283336951.
E-mail
address:
tianx@tmu.edu.cn
(X.
Tian).
1
Xinyu
Xu
and
Yu
Tian
contributed
equally
to
this
work
and
should
be
considered
co-first
authors.
hippocampal
cell
proliferation
and
produced
learning
impairment
in
young
rat
[4].
Working
memory
refers
to
a
cognitive
function
that
provides
concurrent
temporary
storage
and
manipulation
of
the
informa-
tion
necessary
to
perform
complex
cognitive
tasks
[5].
Working
memory
differs
from
short
term
memory
in
that
it
assumes
both
the
storage
and
manipulation
of
information
and
in
the
emphasis
on
its
functional
role
in
complex
cognition
[6].
Working
memory
also
differs
from
long
term
memory
which
is
a
separate
part
of
the
memory
system
with
a
vast
storage
capacity
that
holds
informa-
tion
in
a
relatively
more
stable
form.
Working
memory
is
thought
to
be
involved
in
higher
executive
functioning
such
as
planning
and
sequential
behavior;
deficits
in
working
memory
are
directly
related
to
deficits
in
behavioral
flexibility.
Delayed
alternation
http://dx.doi.org/10.1016/j.bbr.2014.05.034
0166-4328/©
2014
Elsevier
B.V.
All
rights
reserved.
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