Imaging tumor hypoxia: Blood-borne delivery of imaging agents is...

Dedicated to the memory of Professor Britton Chance on the occasion of his 100th birthday (July 24th, 2013), and remembering many exciting discussions on the oxygenation of breast cancer, on tumor hypoxia in general and imaging of the oxygenation status of malignant tumors. Hypoxic tissue subvolumes are a hallmark feature of solid malignant tumors, relevant for cancer therapy and patient outcome because they increase both the intrinsic aggressiveness of tumor cells and their resistance to severa