Recent progress in the biology, chemistry and structural biology...

Recent progress in the biology, chemistry and structural biology of DNA glycosylases Recent progress in the biology, chemistry and structural biology of DNA glycosylases Orlando D. SchaÈ rer* and Josef Jiricny Summary Since the discovery in 1974 of uracil DNA glycosylase (UDG), the first member of the family of enzymes involved in base excision repair (BER), considerable progress has been made in the understanding of DNA glycosylases, the polypeptides that remove damaged or mispaired DNA base