Serum as a modulator of lipoplex-mediated gene transfection: dep...

RESEARCH ARTICLE THEJOURNALOFGENEMEDICINE JGeneMed2000;2:465–476. Serum as a modulator of lipoplex-mediated gene transfection: dependence of amphiphile, cell type and complex stability Sandrine Audouy1 Abstract Grietje Molema2 Lou de Leij2 Background Cationic liposomes belong to the family of non-viral vectors Dick Hoekstra1* forgenedelivery.Despiteseveraldrawbacks,suchaslowefficiencycompared to viruses andinactivationby serum, cationicliposomes remainapromising tool for gene therapy. Therefore f