Ig gene rearrangement in antibody
producing cells
- Southern blot analysis
non lymphoid cell : V,C in the distant
fragments
mature B cell : V,C in the same
fragments
V region of light chain : V gene segment
(VL protein) (VL gene)
J gene segment
(JL gene)
V region of heavy chain : V gene segment
(VH protein) (VH gene)
D gene segment
(DH gene)
J gene segment
(JH gene)
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