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心电监测系统数据分析的智能方法
摘 要
心血管疾病一直严重威胁着人类的生命健康安全,高居全球非传染性疾病死因
首位。 远程心电监测系统能以其便捷高效的诊疗服务模式对预防、 检测和治疗心血
管疾病发挥着重要作用。 但是,如何实现高效率、 高精度的心电信号智能化分析,
是目前远程心电监测系统所面临的主要挑战。 传统的心电分析方法具有诊断效率
低、 精度不高、 适应性差、 泛化能力弱及智能化水 平低等问题,不能满足对心电信
号(Electrocardiogram,ECG)多样性、多变性特点的分析需求。远程心电监测系统
是一类CPS,运用人工智能技术增强其功能,是当前心电监测技 术研究的前沿问题。
人工智能技术 以数据驱动且无需外部假设条件,具有很强的特征提取能力和泛化能
力,为推动新型智慧医疗体系的发展提供了有力的技术支持和工具。 本文针对远程
心电信号智能 化分析过程中的降噪预处理、 特征分割描绘、 心律失常分类识别等关
键任务,从算法模型层面研究AI技术在心电信号智能化分析中的应用,旨在 提高远
程心电医疗的智能化水平。
本文主要工作及学术贡献有:
(1) 提出了 一种基于生成对抗网络(Generative Adversarial Networks,GAN)的
心电信号智能降噪方法。 针对远程环境下采集的ECG信号含有多种类型噪声干扰的
问题,本文以一种新的对抗降噪视角将GAN模型的分布特征学习能力应用到ECG信
号的降噪研究中,有助于 学习不同 噪声类型 的复杂分 布特征,实现了对ECG信号中
包含的多种噪声类型的智能降噪。进一步地,本文设计了新的损失函数稳定了GAN
模型的训练过程,从局部和全局 的角度捕获ECG信号的重要特征,使降噪后的ECG
信号能够保留其医用价值而不失真。 基于MIT-BIH心电数据库的实验结果表明,本
文 所提出的方法优于其他先进方法,并将信噪比SNR平均提升了约62%,具有良好
的降噪能力,适应性强。
(2) 提出了一种基于编码器-解码器(Encoder-Decoder)模型的心电信号智能分
割方法。 针对ECG信号所具有的多样性和多变性特点,本文利用编码器-解码器模
型优越的特征提取能力提取ECG信号中的隐藏特征并生成相应的矩形波分割描绘
结果,实现了对ECG信号中P波、 QRS波群和T波起止点的分割描绘。 进一步地,本
文设计了一种知识编码和对齐方法,将不同类型的医学知识融入ECG信号的分割描
绘过程中,提高了模型对ECG信号的分割描绘性能以及对不同个体ECG信号的适应
性。在QT心电数据库上的实验结果表明,本文所提出的方法 能够准确高效地描绘出
心电信号中的关键 点位置,平均灵敏度和查准率结果分别高达99.62%和99.81%,并
且能在噪声干扰的情况下取得90%以上的灵敏度和查准率。
(3) 提出了一种人机协同知识表示的可解释性心律失常分类方法。 针对心律失
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博士学位论文
常分类识别问题,提出了一种适用于ECG信号特征的可解释性心律失常分类识别方
法。 针对深度心律失常分类模型端到端的“黑盒” 问题,本文设计了一种人机协
同知识表示用 于心律失常分类识别,提高了模型的可解释性。利 用自编码器结合监
督学习和无监督学习设计了一种两任务学习方法生成人机 协同知识表示,有利于提
取ECG信号中的多层次隐藏特征。 针对模型的交互性差这一问 题,建立了一种人在
环中(Human-in-the-loop,HIL)的交互诊断机制来干预深度模型的推理过程,以此
来提高模型的交互能力和分类性能。 在 MIT-BIH 心律失常数据库上的实验结果表
明,本文所提出的方法能够对心律失常进行有效分类的同时提供可解释性的分类依
据,并且该方法可以通过使用HIL机制调整人工编码知识来 提高模型的交互性和分
类性能。
本文提出的远程医疗环境下心电信号的智能分析方法,可有效提高医生的工作
效率,减轻远程医 疗环境带来的问题,对及早地预防、 检测和治疗心血管疾病,提
升远程心电监测系统的智能化水平,缓解我国医疗资源匮乏不均和医疗 体系失衡问
题,都具有重大意义。
关键词: 远程心电监测系统; 心电数据分析; 人工智能; 可解释性分类;
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心电监测系统数据分析的智能方法
Abstract
As the first cause of death of non-communicable diseases in the world, cardiovascular
disease has been a serious threat to human life and health. The remote ECG monitoring
system plays an important role in the prevention, detection and treatment of cardiovascular
diseases with its convenient and efficient diagnosis mode. However, how to achieve intelli-
gent analysis of ECG signals with high efficiency and accuracy is the main challenge faced
by remote ECG monitoring system. Traditional ECG analysis methods have problems such
as low diagnostic efficiency, low accuracy, poor adaptability, weak generalization ability,
and low level of intelligence, which cannot meet the analysis requirements for the diversity
and variability of ECG signals. The Remote ECG monitoring system is a kind of CPS. It is
the frontier research of ECG monitoring to enhance the system’s function by using artificial
intelligence technology. Artificial intelligence (AI) technology is data-driven and does not
require external data assumptions, which has strong capabilities of feature extraction gener-
alization. AI provides powerful technical support and tools for promoting the development
of new smart medical systems. Aiming at key tasks such as noise reduction, dielineation,
arrhythmia classification in the remote ECG analysis process, this paper studies the applica-
tion of AI technology in the intelligent analysis of ECG signals from the level of algorithm
and model, thus improving the intelligent level of the remote ECG analysis process.
The main work and academic contributions of this paper are as follows.
(1) A method of noise reduction for ECG signals based on generative adversarial net-
work (GAN) is proposed. Aiming at the problem that ECG signals collected in the remote
environment contain various types of noise, this paper applies the distribution feature learn-
ing ability of the GAN model to the noise reduction study of the ECG signal based on the
adversarial perspective, which helps to learn the complex distribution features of various
noise, and realizes the intelligent denoising for multiple types of noise contained in ECG
signals. Furthermore, this paper designs a new loss function to stabilize the training process
of the GAN model and capture the important local and global features of ECG signals, so
that the denoised ECG signal can retain its medical value without distortion. Experimental
results based on MIT-BIH Arrhythmia database show that the proposed method is superior
to other methods, and the SNR is improved by about 62% on average. The proposed method
has good noise reduction ability and strong adaptability.
(2) A deep learning method for ECG signal delineation based on encoder-decoder
IV
博士学位论文
model is proposed. In view of the diversity and variability of ECG signals, this paper uses
the encoder-decoder model with superior feature extraction capability to extract the hid-
den features in ECG signals and generate the corresponding rectangular wave to delineate
both the onset and offset of the P wave, the QRS complex, and the T wave in ECG signals.
Furthermore, this paper designs a knowledge encoding and alignment method to integrate
different types of medical knowledge into the ECG delineation process, which improves
the delineation performance of the model for ECG signals and the adaptability to different
individual ECG signals. An evaluation conducted on the QT database demonstrates that the
proposed method can obtain, on average, high performance with sensitivity of 99.62% and
positive predictivity of 99.81%. The evaluation also shows that the method can obtain a
sensitivity and a positive predictivity above 90% in most noisy cases.
(3) An interpretable arrhythmia classification method with human-machine collabora-
tive knowledge representation is proposed. Aiming at the problem of automatic recognition
and diagnosis of multi-class arrhythmias, an interpretable arrhythmia classification method
suitable for ECG signal characteristics is proposed. Aiming at the end-to-end “black box”
problem of the deep classification model, a human-machine collaborative knowledge repre-
sentation is designed to improve the interpretability of the model for automatic classification
of arrhythmia. Combining supervised learning and unsupervised learning, the proposed ap-
proach designs a two-task learning method based on an AutoEncoder (AE) to encode ECG
signals into human-machine collaborative knowledge representation. Aiming at the prob-
lem of poor interaction of the classification model, a human-in-the-loop (HIL) mechanism
is established to allow human intervention with the inference of the neural network to im-
prove the model’s interactive ability and classification performance. Experiments and eval-
uation on the MIT-BIH arrhythmia database demonstrate that our new approach not only
can effectively classify arrhythmia while offering interpretability, but also can improve the
interaction and classification accuracy by adjusting the hand-encoding knowledge with the
HIL mechanism.
The intelligent analysis method of ECG signals in the telemedicine environment pro-
posed in this paper can effectively improve the work efficiency of doctors and alleviate the
problems caused by the telemedicine environment. It is of great significance for the early
prevention, detection and treatment of cardiovascular diseases, improving the intelligent
level of the remote ECG monitoring system, and alleviating the lack of uneven medical
resources and the imbalance of the medical system in our country.
Key Words: Remote ECG Monitoring System; ECG Data Analysis; Artificial Intelligence;
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心电监测系统数据分析的智能方法
Interpretable Classification;
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