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ABSTRACT
III
ABSTRACT
Sleep Apnea Syndrome (SAS) is a common sleep disorder that has a serious impact on
the quality of sleep and daily life of people. Polysomnography is a gold standard for the
diagnosis of sleep apnea syndrome, which is complex to implement, has a large number of
leads, and can easily affect the quality of sleep of patients during implementation. It has been
shown in the literature that characteristic parameters in the ECG signal can characterize SAS,
and many existing methods are based on single-channel ECG signals for SAS detection, but
the accuracy of these methods is not high. Many experts have studied the relationship between
changes in oxygen saturation during sleep and SAS, and the results show that blood oxygen
saturation has a high correlation with SAS. Therefore, this thesis uses the method of fusion of
ECG signal and blood oxygen saturation characteristics to detect sleep apnea syndrome, and
designs and develops a sleep apnea syndrome monitoring system to improve the accuracy of
the detection results. The main contents of the thesis are as follows:
(1) ECG signal and oxygen saturation signal preprocessing. In this thesis, firstly, the ECG
signal and oxygen saturation signal are segmented, each segment is 5 minutes; the median
filter is used to remove the baseline drift in the ECG signal; the 50Hz FIR trap is used to
remove the industrial frequency interference in the ECG signal; the Butterworth filter is
designed to remove the high frequency noise in the ECG signal; the moving average filter is
used to remove the abnormal values in the oxygen saturation signal.
(2) To investigate SAS characterization methods based on the fusion of multimodal
physiological signal features. In this thesis, the Pan-Tompkins algorithm was used to detect
the position of the R peak in the ECG signal, calculate the RR interval and heart rate variability
of the ECG signal, and extract the feature parameters that can characterize SAS on this basis;
after removing the abnormal value data in the blood oxygen saturation, the feature parameters
were extracted and fused with the feature parameters of the ECG signal to characterize SAS.
(3) To study an algorithmic model for sleep apnea syndrome detection based on an
improved LeNet-5 convolutional neural network. Compared with the original LeNet-5
convolutional neural network, this model uses one-dimensional convolutional operations
广东工业大学硕士专业学位论文
IV
instead of two-dimensional convolutional operations for feature extraction, and adds a
shedding layer to the network to prevent overfitting, which reduces the complexity of the
model and improves the detection of SAS on the data sets. The model uses the signal features
of fused ECG signal and blood oxygen saturation as input, and the accuracy obtained from the
detection of SAS on Apnea database is 86.0%, which is 3.4% more accurate than that of single-
channel ECG signal as input to the model; the accuracy obtained from the detection on
UCDDB database is 79.0%, which is 0.3% more accurate than that of single-channel ECG
signal as input to the model. The results show that it is more advantageous to use multimodal
feature fusion to detect SAS.
(4) Design and implementation of a sleep apnea syndrome monitoring system. The
system can continuously collect the ECG signal and blood oxygen saturation of patients
sleeping at night with waveform display and history review; the system implements the sleep
apnea syndrome detection algorithm in practical applications, and can be used for automatic
sleep apnea detection in hospital or home environment with certain practicality.
Key words: SAS; ECG signal; Oxygen saturation; LeNet-5 convolution neural network
目录
V
目录
摘要 ........................................................................................................................................... I
ABSTRACT ..........................................................................................................................III
目录 ......................................................................................................................................... V
CONTENTS ....................................................................................................................... VIII
第一章 绪论 .......................................................................................................................... 1
1.1 研究背景及研究意义 ............................................................................................... 1
1.2 国内外相关研究现状 ............................................................................................... 3
1.2.1 基于心电信号分析方法现状 ........................................................................ 3
1.2.2 基于血氧饱和度的分析方法现状 ................................................................ 4
1.2.3 基于组合信号分析方法现状 ........................................................................ 5
1.3 论文研究内容及章节安排 ....................................................................................... 6
1.4 课题来源 ................................................................................................................... 7
第二章 心电信号、血氧饱和度与 SAS 分析的基本理论 .................................................. 8
2.1 心电信号、血氧饱和度与 SAS 的关系 .................................................................. 8
2.2 心电信号分析 ........................................................................................................... 9
2.3 血氧饱和度分析 ..................................................................................................... 11
2.4 卷积神经网络相关理论概述 ................................................................................. 12
2.5 Apnea-ECG 数据库 ................................................................................................. 14
2.6 UCDDB 数据库 ....................................................................................................... 15
2.7 本章小结 ................................................................................................................. 16
第三章 心电信号和血氧饱和度预处理 .............................................................................. 17
3.1 心电信号预处理 ..................................................................................................... 17
3.1.1 中值滤波器设计 ........................................................................................... 17
3.1.2 FIR 陷波器的设计 ........................................................................................ 20
3.1.3 Butterworth 滤波器设计 ............................................................................... 22
3.2 血氧饱和度预处理 ................................................................................................. 23
3.3 本章小结 ................................................................................................................. 24
广东工业大学硕士专业学位论文
VI
第四章 SAS 相关特征提取 ................................................................................................. 25
4.1 心电信号特征参数提取 ......................................................................................... 25
4.1.1 R 峰检测 ....................................................................................................... 25
4.1.2 RR 间期与心率变异性关系 ......................................................................... 28
4.1.3 心率变异性分析 .......................................................................................... 29
4.2 血氧饱和度特征参数提取 ..................................................................................... 33
4.3 SAS 相关特征提取 ................................................................................................. 33
4.4 本章小结 ................................................................................................................. 34
第五章 基于改进的 LeNet-5 卷积神经网络的睡眠呼吸暂停检测 .................................. 35
5.1 LeNet-5 卷积神经网络 ........................................................................................... 35
5.2 LeNet-5 卷积神经网络模型的改进 ........................................................................ 36
5.2.1 改进思路 ...................................................................................................... 36
5.2.2 改进模型的设计 .......................................................................................... 36
5.3 改进的 LeNet-5 卷积神经网络检测实验及结果分析 .......................................... 38
5.3.1 评估标准 ...................................................................................................... 38
5.3.2 实验及结果分析 .......................................................................................... 39
5.3.3 与其它方法的分类效果对比 ...................................................................... 43
5.4 本章小结 ................................................................................................................. 48
第六章 睡眠呼吸暂停综合征监测系统实现 ...................................................................... 49
6.1 睡眠呼吸暂停综合征监测系统组成 ..................................................................... 49
6.2 睡眠呼吸暂停综合征监测系统工作流程及实现 ................................................. 50
6.2.1 睡眠呼吸暂停综合征监测系统软件工作流程 .......................................... 50
6.2.2 睡眠信号监控实现 ...................................................................................... 52
6.2.3 睡眠质量历史数据回顾 .............................................................................. 53
6.3 本章小结 ................................................................................................................. 56
总结与展望 ............................................................................................................................ 57
参考文献 ................................................................................................................................ 59
攻读学位期间取得与学位论文相关的成果 ........................................................................ 65
目录
VII
学位论文独创性声明 ............................................................................................................ 66
致 谢 ...................................................................................................................................... 67
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