# colearn
A deep learning technique for the spatially varying fusion of spatially-aligned feature maps from multi-modality medical images.
## Dependencies
- tensorflow-gpu 1.10+
- CUDA 9.0
- CuDNN 7.0
- python3
- numpy
- Pillow
This version has only been tested on Ubuntu 16.04 on an NVIDIA GTX 1080 Ti.
## Usage
An example architecture is included [here](src/colearn_cnn.py). A main function to use the architecture on PET-CT data is also [included](src/colearn_cnn_petct_main.py).
### Data Preparation
The example main file expects PET-CT lung data in the TFRecord format.
```python
'height': tf.FixedLenFeature([], tf.int64) # height of the image
'width': tf.FixedLenFeature([], tf.int64) # width of the image
'depth': tf.FixedLenFeature([], tf.int64) # deprecated will be removed
'ct': tf.FixedLenFeature([], tf.string) # CT image (height * width * 1)
'pt': tf.FixedLenFeature([], tf.string) # PET image (height * width * 1)
'ctlb': tf.FixedLenFeature([], tf.string) # binary masks of anatomical regions (height * width * 2)
'ptlb': tf.FixedLenFeature([], tf.string) # binary mask of tumours (height * w * 1)
'bglb': tf.FixedLenFeature([], tf.string) # binary mask of background (height * width * 1)
```
For the anatomical binary masks, the two channels (depth dimension of 2) are for the lung fields and the mediastinum.
### Training
To train using default parameters on a GPU, use:
```
python3 colearn_cnn_petct_main.py \
--mode=train \
--train_data_path=TRAIN_DATA_PATH \
[--valid_data_path=VALID_DATA_PATH] \
--log_root=LOG_ROOT \
--train_dir=LOG_ROOT/TRAIN_DIR \
[--valid_dir=LOG_ROOT/VALID_DIR]
```
where:
- `TRAIN_DATA_PATH` is the directory with the \*.tfrecord files for the training data
- `VALID_DATA_PATH` is the directory with the \*.tfrecord files for the validation data
- `LOG_ROOT` is the directory where the logs for this run will be stored
- `TRAIN_DIR` is the subdirectory of `LOG_ROOT` for training logs
- `VALID_DIR` is the subdirectory of `LOG_ROOT` for validation logs
If `VALID_DATA_PATH` is not specified, there will be no outputs for model validation.
If `VALID_DATA_PATH` is specified, then `VALID_DIR` must also be specified.
### Evaluation
To evaluate your trained model, use:
```
python3 colearn_cnn_petct_main.py \
--mode=eval \
--eval_data_path=EVAL_DATA_PATH \
--log_root=LOG_ROOT \
--eval_dir=LOG_ROOT/EVAL_DIR \
--checkpoint_to_eval=CKPT_TO_EVAL \
```
where:
- `EVAL_DATA_PATH` is the directory with the \*.tfrecord files for the evaluation data
- `LOG_ROOT` is the directory where the logs for this run will be stored
- `EVAL_DIR` is the subdirectory of `LOG_ROOT` for evaluation logs
- `CKPT_TO_EVAL` is the integer number of the training checkpoint to evaluate
## Citation
If you make use of this code in your work, please cite the following paper:
`A. Kumar, M. Fulham, D. Feng, and J. Kim, "Co-Learning Feature Fusion Maps from PET-CT Images of Lung Cancer", arXiv:1810.02492, 2018.`
[Link to Paper](https://arxiv.org/abs/1810.02492).
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