论文研究 - 不同放疗技术对左乳腺癌第二次癌症风险的影响
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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology, 2018, 7, 193-202
http://www.scirp.org/journal/ijmpcero
ISSN Online: 2168-5444
ISSN Print: 2168-5436
DOI:
10.4236/ijmpcero.2018.72017 May 28, 2018 193
Int
. J. Medical Physics, Clinical Engineering and Radiation Oncology
Influence of Distinct Radiotherapy Techniques
to Induce Second Cancer Risks in Left Breast
Cancer
Raghda A. Elgendy
1
, Wahib M. Attia
2
, Ehab M. Attalla
3
, Mostafa A. Elnaggar
1,4
1
Medical Physics Department, Ayady Al Mostakbal Oncology Center, Alexandria, Egypt
2
Physics Department, Faculty of Science, Suez Canal University, Ismailia, Egypt
3
Radiotherapy and Nuclear Medicine Department, National Cancer Institute, Cairo University, Giza, Egypt
4
Cancer Management and Research Department, Medical Research Institute, Alexandria University, Alexandria, Egypt
Abstract
Influence of distinct radiotherapy techniques to induce second cancer risks in
left breast cancer.
Material and methods: Ten female patients with intact left
breast cancer. Two treatment plans for each patient: 1)
two tangential beams
3D-Conformal radiotherapy, 2) intensity-
modulated radiotherapy (IMRT)
plan. Estimation of second cancer risk from Organ equivalent dose models
(OEDs) in three dose-response model for organs at risk in lef
t breast cases.
Results: The P-value for OED models in 3D-IMRT for left lung, bot
h lung,
heart, right lung, right breast, thyroid, liver and spinal cord in linear dose
model was 0.016, 0
.005, 0.019, 3.95E−06, 5.79E−07, 0.003, 1.78E−10 and
0.000206475 respectively, for linear exponential dose model 0.0577, 0.024,
0.031, 3.40E−06, 3.28E−
07, 0.003, 2.01E−10 and 0.000120072 respectively and
in plateau dose model 0.088, 0.042, 0.039, 3.18E−06, 2.53E−07, 0.003,
2.27E−10 and 9.00535E−05 respectively. Conclusion: organ equivalent dose
models for organs at risk increasing in IMRT than tangential beams.
Keywords
Breast Cancer, Second Cancer Risks, 3DCRT, 7 Field IMRT
1. Introduction
The most common cancer in US women patients is breast cancer, which is the
second reason for death in cancer patients. Statistics evaluate that eighth of
women of America can get breast cancer [1].
Mastectomy is the traditional therapy for breast. Where nearly 1.7/3 of wom-
How to cite this paper:
Elgendy, R.A.,
Attia, W
.M., Attalla, E.M. and Elnaggar,
M
.A. (2018) Influence of Distinct Radio-
therapy Techniques to Induce Second
Cancer Risks in Left Breast Cancer.
International Journal of Medical Physics
,
Clinical Engineering and Radiation
Oncology
,
7
, 193-202.
https://doi.org/10.4236/ijmpcero.2018.72017
Received:
April 18, 2018
Accepted:
May 25, 2018
Published:
May 28, 2018
Copyright © 201
8 by authors and
Scientific
Research Publishing Inc.
This work is licensed under the Creative
Commons Attribution
International
License (CC BY
4.0).
http://creativecommons.org/licenses/by/4.0/
Open Access
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