Apoptosis in cancer: cause and cure

Apoptosis in cancer: cause and cure Apoptosis in cancer: cause and cure Scott H. Kaufmann1* and Gregory J. Gores2 Summary The accumulation of neoplastic cells can occur through enhanced proliferation, diminished cell turnover, or a combination of both processes. Although the potential contribution of diminished cell turnover to tumor devel- opment has been appreciated for a decade, more recent studies in animal models and clinical cancer specimens have elucidated the mechanisms by which alter