Apoptosis in cancer: cause and cure
Apoptosis in cancer:
cause and cure
Scott H. Kaufmann1* and Gregory J. Gores2
Summary
The accumulation of neoplastic cells can occur through
enhanced proliferation, diminished cell turnover, or a
combination of both processes. Although the potential
contribution of diminished cell turnover to tumor devel-
opment has been appreciated for a decade, more recent
studies in animal models and clinical cancer specimens
have elucidated the mechanisms by which alter
