HUS1 (HUS1 checkpoint homolog (S. pombe)).pdf
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Gene Section
Review
Atlas Genet Cytogenet Oncol Haematol. 2011; 15(5)
455
Atlas of Genetics and Cytogenetics
in Oncology and Haematology
OPEN ACCESS JOURNAL AT INIST-CNRS
HUS1 (HUS1 checkpoint homolog (S. pombe))
Amrita Madabushi, Randall C Gunther, A-Lien Lu
Department of Biochemistry and Molecular Biology, School of Medicine, University of Maryland, 108
North Greene Street, Baltimore, Maryland 21201, USA (AM, RCG, ALL)
Published in Atlas Database: September 2010
Online updated version : http://AtlasGeneticsOncology.org/Genes/HUS1ID40899ch7p12.html
DOI: 10.4267/2042/45024
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 2.0 France Licence.
© 2011 Atlas of Genetics and Cytogenetics in Oncology and Haematology
Identity
HGNC (Hugo): HUS1
Location: 7p12.3
Note: NCBI accession: NM_004507.2; NP_004498.1.
DNA/RNA
Description
15464 bp; 8 exons.
Transcription
The transcribed mRNA has 2143 bp and the coding
region is 840 bp, encodes a 280 amino acids, 31691 Da
protein.
Pseudogene
None.
Protein
Description
Amino acids: 280. Molecular weight: 31.7 kDa. Hus1
is a component of the 9-1-1 cell cycle checkpoint
complex that plays a critical role in sensing DNA
damage and maintaining genomic stability.
Expression
Found in all tissues.
Localisation
Nucleus and cytoplasm. In discrete nuclear foci upon
DNA damage.
Figure 1. HUS1 gene adapted from NCBI database Homo sapiens chromosome 7, GrCh37 primary reference assembly with kilobases
from the telomere of p-arm on bottom. The exons 1-8 are represented by boxes with transcribed and untranscribed sequences in pink
and orange, respectively. The exon numbers are labeled on top. The grey arrowhead symbolizes the direction of transcription and the
arrows show the ATG and the stop codons, respectively.
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