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Machine Learning in Medicine
Ton J. Cleophas • Aeilko H. Zwinderman
Machine Learning
in Medicine
by
TON J. CLEOPHAS, MD, PhD, Professor,
Past-President American College of Angiology,
Co-Chair Module Statistics Applied to Clinical Trials,
European Interuniversity College of Pharmaceutical Medicine, Lyon, France,
Department Medicine, Albert Schweitzer Hospital, Dordrecht, Netherlands,
AEILKO H. ZWINDERMAN, MathD, PhD, Professor,
President International Society of Biostatistics,
Co-Chair Module Statistics Applied to Clinical Trials,
European Interuniversity College of Pharmaceutical Medicine, Lyon, France,
Department Biostatistics and Epidemiology, Academic Medical Center, Amsterdam,
Netherlands
With the help from
EUGENE P. CLEOPHAS, MSc, BEng,
HENNY I. CLEOPHAS-ALLERS.
Ton J. Cleophas
European College Pharmaceutical Medicine
Lyon, France
Aeilko H. Zwinderman
Department of Epidemiology
and Biostatistics
Academic Medical Center
Amsterdam
Netherlands
Please note that additional material for this book can be downloaded from
http://extras.springer.com
ISBN 978-94-007-5823-0 ISBN 978-94-007-5824-7 (eBook)
DOI 10.1007/978-94-007-5824-7
Springer Dordrecht Heidelberg New York London
Library of Congress Control Number: 2012954054
© Springer Science+Business Media Dordrecht 2013
This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of
the material is concerned, speci fi cally the rights of translation, reprinting, reuse of illustrations, recitation,
broadcasting, reproduction on micro fi lms or in any other physical way, and transmission or information
storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology
now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection
with reviews or scholarly analysis or material supplied speci fi cally for the purpose of being entered and
executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this
publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s
location, in its current version, and permission for use must always be obtained from Springer. Permissions
for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to
prosecution under the respective Copyright Law.
The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication
does not imply, even in the absence of a speci fi c statement, that such names are exempt from the relevant
protective laws and regulations and therefore free for general use.
While the advice and information in this book are believed to be true and accurate at the date of
publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for
any errors or omissions that may be made. The publisher makes no warranty, express or implied, with
respect to the material contained herein.
Printed on acid-free paper
Springer is part of Springer Science+Business Media (
www.springer.com)
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