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ABSTRACT
II
ABSTRACT
With the development of economy and society, peoples attention to their own health
has gradually increased, which has also led to the flourishing development of wearable
biomedical sensors. Wearable biomedical sensors enable real-time monitoring of human
health and timely warning of possible abnormalities in the body, thereby reducing the
prevalence, severity and mortality of users. A bioelectric signal acquisition and sensing
system with excellent performance needs an analog front-end circuit with low power
consumption, low size, low noise and high interference suppression capability.
Bioelectric signal has the characteristics of low frequency and low amplitude, and is
very vulnerable to external environmental interference and the noise of its own circuit.
For two-electrode ECG signal acquisition system, the peak value of common mode
interference signal coupled to human body by surrounding power lines can be as high as
tens of volts, leading to the saturation of the front-end circuit. There is a large impedance
mismatch between the dry electrode models, which will affect the common mode
rejection ratio (CMRR) of the front-end circuit system, and will introduce the error of
common mode slip mode. The electrodes react with human skin by introducing a larger
DC electrode offset (DEO) voltage. In addition, the presence of an impedance voltage
component in the signal pathway can cause signal attenuation. Finally, the noise in the
front-end circuit will affect the accuracy of signal collection.
To solve the above problems, this thesis presents a front-end circuit for two-electrode
ECG acquisition, which is mainly composed of common-mode interference suppression
module and signal amplification module. The signal amplification module is composed
of instrument amplifier module and programmable gain amplifier (PGA) module
combined with input impedance lifting technology. In this design, a common mode
interference suppression module circuit is proposed to suppress the common mode
interference signal. The integrated common mode replication technology can greatly
increase the common mode input impedance to weaken the influence of electrode
mismatch on the common mode rejection ratio. An adaptive input impedance lifting loop
is presented to reduce the influence of input capacitance and input parasitic capacitance
on the input differential mode impedance of the signal amplifier module. A capacitive
coupled instrumentation amplifier is used to reduce the system mismatch caused by poor
ABSTRACT
III
resistance matching compared with capacitance, and to achieve the performance index of
low noise and low power consumption. Finally, three-pass gain (12/18/24 dB) adjustable
PGA modules are used to meet different application scenarios. Based on 180nm BCD
process, common mode interference signal with peak value up to 30 V
PP
is suppressed at
1.8 V power supply voltage. The total circuit transient output ENOB is 11.9 bit, SNR is
73.76 dB and SFDR is 74.91 dB. For the signal amplifier module, the total current
consumption to achieve is 3.41 μ A; With 100% electrode mismatch (1M||10nF), the
CMRR was 119.312 dB and the power rejection ratio was 119.508. At 50 Hz, the common
mode input impedance is 272.54 GΩ and the differential mode input impedance is 5.12
GΩ. Equivalent input integral noise is 2.43 μV in the frequency range 0.5-150 Hz.
Keywords: ECG Signal, Front End Circuit, Common Mode Interference Suppression,
Impedance Promotion, Common Mode Rejection Ratio(CMRR)
目 录
IV
目 录
第一章 绪论 ························································································ 1
1.1 研究背景与意义 ········································································· 1
1.2 研究历史与研究现状 ··································································· 3
1.3 本文主要内容与创新点 ································································ 8
1.4 本文的结构与安排 ···································································· 10
第二章 生物电信号读出模拟前端架构概述 ··············································· 11
2.1 生物电信号介绍 ······································································· 11
2.1.1 生物电信号的产生机理 ······················································ 11
2.1.2 生物电信号的类型与特征 ··················································· 11
2.2 生物电极介绍 ·········································································· 13
2.3 常见的干扰源 ·········································································· 14
2.3.1 直流电极失调电压 ···························································· 14
2.3.2 工频干扰 ········································································ 15
2.3.3 运动伪影干扰 ·································································· 17
2.3.4 低频噪声 ········································································ 17
2.4 AFE 系统架构分析 ····································································· 18
2.4.1 设计要点 ········································································ 18
2.4.2 生物电信号采集前端系统架构 ············································· 20
2.5 本章小结 ················································································ 20
第三章 系统关键模块结构与分析 ··························································· 21
3.1 共模干扰抑制模块 ···································································· 21
3.1.1 右腿驱动电路 ·································································· 21
3.1.2 共模电荷泵 ····································································· 22
3.2 仪表放大器 ············································································· 24
3.2.1 三运放结构 IA ································································· 24
3.2.2 两运放结构 IA ································································· 25
3.2.3 CBIA ·············································································· 26
3.2.4 CCIA ·············································································· 27
3.3 PGA 模块 ················································································ 28
3.3.1 电阻反馈型 PGA ······························································· 28
目 录
V
3.3.2 电容反馈型 PGA ······························································· 29
3.3.3 电容翻转型 PGA ······························································· 29
3.4 本章小结 ················································································ 30
第四章 系统电路的设计与仿真 ······························································ 31
4.1 电路原理及设计实现 ································································· 31
4.1.1 两电极系统等效输入模型 ··················································· 31
4.1.2 共模干扰抑制模块 ···························································· 32
4.1.3 MOS 伪电阻 ····································································· 39
4.1.4 CCIA 设计 ······································································· 41
4.1.5 共模复制技术 ·································································· 45
4.1.6 自适应输入阻抗提升技术 ··················································· 47
4.1.7 PGA 设计 ········································································ 51
4.2 电路仿真结果与分析 ································································· 52
4.2.1 MOS 伪电阻仿真 ······························································· 52
4.2.2 共模干扰抑制模块仿真 ······················································ 54
4.2.3 信号放大模块仿真 ···························································· 57
4.2.4 前端整体模块仿真 ···························································· 70
4.3 版图设计与后仿真 ···································································· 71
4.3.1 部分模块版图设计要点 ······················································ 72
4.3.2 电路版图后仿真 ······························································· 73
4.4 仿真性能参数总结 ···································································· 74
4.5 本章小结 ················································································ 75
第五章 总结与展望 ············································································· 76
5.1 工作总结 ················································································ 76
5.2 未来展望 ················································································ 77
致 谢 ···························································································· 78
参考文献 ··························································································· 79
攻读硕士学位期间取得的成果 ································································ 83
第一章 绪论
1
第一章 绪论
1.1 研究背景与意义
随着中国全面小康社会的建成,我 们 历史性地解决了绝对贫困问题,我们的社
会经济建设发展迅速,人们的生活水平日益提升。当然,经济社会的飞速发展也会
引发一定的问题,人民的生活方式在此期间发生了深刻的变化,存在生活方式不科
学、饮食习惯不良好、工作时长较高、工作压力较大等的人们越来越多,人们的身
体普遍存在健康问题。这也使得更多的人们开始关注自身的健康状况。
最新发布的《中国心血管健康与疾病报告 2022 概要》指出
[1]
,心血管疾病在
众多疾病中致死率稳占前列,致死率甚至要高于人们谈虎色变的“癌症”,患病率
有逐步增长的趋势,引起了人们的极大关注。
如图 1-1 所示为 2000~2019 年中国城乡居民心血管病死亡率变化曲线图,其
中,心血管疾病的死亡率自 2006 年起呈逐渐递增的趋势,自 2009 年起农村居民
的死亡率均要高于城市居民,且两者死亡率的差距有扩大的趋势。
如图 1-2 所示为 2019 年中国城乡居民的主要疾病死因构成比扇形图,其中,
心血管疾病在城乡居民主要疾病死因中均占首位,分别高达 46.74%和 44.26%。
由此可见,心血管疾病在中国是威胁城乡居民生命安全的主要因素之一,人 们
不得不开始加大对心血管疾病的关注。
图 1-1 中国城乡居民心血管病死亡率变化曲线图
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